Ultraviolet Light-Induced Pathology in the Eye: Associated Changes in Ocular Aldehyde Dehydrogenase and Alcohol Dehydrogenase Activities
作者:
John Downes,
Peter Swann,
Roger Holmes,
期刊:
Cornea
(OVID Available online 1993)
卷期:
Volume 12,
issue 3
页码: 241-248
ISSN:0277-3740
年代: 1993
出版商: OVID
关键词: UV light;Aldehyde dehydrogenase;Alcohol dehydrogenase;Mouse;Lens
数据来源: OVID
摘要:
Adult male C57BL/6J inbred mice were subjected to ultraviolet radiation (UVR) exposure (302-nm peak wavelength; average intensity 282 (µ W/cm2) for 1 h and monitored for ocular aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) activity changes over a period of 25 days. Dramatic reductions in activities were observed by 4-6 days postexposure, resulting in enzyme levels of 15-16% of control animals. Major decreases in corneal enzyme levels were predominantly responsible for these changes. Ocular morphology was observed throughout using a photoslit-lamp biomicroscope, with maximum corneal clouding occurring at days 4-6. These data support earlier proposals for major roles for these corneal enzymes in assisting the cornea in protecting the eye against UVR-induced tissue damage.
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