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Acute and Delayed Emesis after Cisplatin-Based Regimen: Description and Prevention

 

作者: Christophe Louvet,   Andre Lorange,   Francois Letendre,   Raymond Beaulieu,   Harry M. Pretty,   Yves Courchesne,   Jean A. Neemeh,   Marc Monte,   Jean Latreille,  

 

期刊: Oncology  （Karger Available online 1991）
卷期: Volume 48, issue 5  

页码: 392-396

 

ISSN:0030-2414

 

年代: 1991

 

DOI:10.1159/000226966

 

出版商: S. Karger AG

 

关键词: Cisplatin;Emesis;delayed;Lorazepam;Dexamethasone;Metoclopramide

 

数据来源: Karger

 

摘要:

Lorazepam, dexamethasone and high-dose metoclopramide were given to 54 patients to prevent emesis induced by cisplatin (50–120 mg/m2 2 episodes occurred in 70, 11 and 19%, respectively. Overall control (days 1–8) was complete in 55.5% and satisfactory ≤2 emeses on day 1 and/or < 2 emeses from days 2 to 8) in 74%. Delayed emesis started on days 2–5. Mean duration was 2.6 days. Delayed nausea or emesis were more frequent when emesis occurred on day 1. Based on data previously reported and on these observations, better ways to prevent delayed events are discussed. Further trials must record systematically delayed s

 

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