Regulation of Procoagulant Factors in Mononuclear Phagocytes
作者:
Roger T. Dean,
Patricia Leoni,
Bartira C. Rossi,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1984)
卷期:
Volume 14,
issue 5
页码: 412-421
ISSN:1424-8832
年代: 1984
DOI:10.1159/000215099
出版商: S. Karger AG
关键词: Infections;Mononuclear phagocytes;Procoagulants;Thromboplastin;Trypanosomes
数据来源: Karger
摘要:
Mononuclear phagocytes can be activated to develop enhanced expression of a wide range of macromolecules and mediators. Amongst these are several procoagulants, most notably thromboplastin. A variety of stimuli (particles, ligands for cell surface receptors, and some pharmacological agents) enhance procoagulant expression. We indicate that such enhancement may contribute to intra-and extravascular coagulation in several types of infections. We also point to the paucity of knowledge on the biosynthesis and intracellular transport of these procoagulants and speculate on the nature of the mechanisms involved.
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