Assessment of Cognitive Performance after Progesterone Administration in Healthy Male Volunteers
作者:
Georg Grön,
Elisabeth Friess,
Martin Herpers,
Rainer Rupprecht,
期刊:
Neuropsychobiology
(Karger Available online 1997)
卷期:
Volume 35,
issue 3
页码: 147-151
ISSN:0302-282X
年代: 1997
DOI:10.1159/000119336
出版商: S. Karger AG
关键词: Progesterone;Attention;Neurosteroids;Neuroactive steroids
数据来源: Karger
摘要:
Administration of progesterone produces sleep EEG patterns that resemble those of agonistic modulators at the GABAA receptor. Previous studies evaluating the effects of an oral progesterone administration on attention performance in females pointed to putative sedative effects of progesterone at high dosages. However, no data are available whether progesterone dosages that influence sleep produce sedative hangover effects on the following morning. Therefore, we assessed the effects of a single oral dose of 300 mg micronized progesterone administered in the evening on cognitive performance parameters in male healthy volunteers on the following morning using a placebo-controlled double-blind crossover design. There was a great variability in bioavailability following progesterone intake. The administration of progesterone produced no consistent effects on attention performance. Thus, dosages of progesterone that are sufficient to modulate sleep are not likely to exert sedative hangover effects.
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