Influence of molecular structure on the synergistic action of theophylline or dipyridamole derivatives in the prostaglandin-type inhibition of platelet aggregation
作者:
C.H. Bamford,
I.P. Middleton,
K.G. Al-Lamee,
期刊:
Journal of Biomaterials Science, Polymer Edition
(Taylor Available online 1991)
卷期:
Volume 2,
issue 1
页码: 37-52
ISSN:0920-5063
年代: 1991
DOI:10.1163/156856291X00043
出版商: Taylor & Francis Group
关键词: Platelet aggregation;inhibition by prostaglandins;potentiation by phosphodiesterase inhibitors;membrane permeabilities
数据来源: Taylor
摘要:
Approximately 30 new derivatives of theophylline and dipyridamole have been prepared and examined as potentiators of the inhibition of platelet aggregation induced by the prostaglandin analogue BW 245C. Potentiating activity has been found to be sensitive to molecular size and also to the presence of specific groups. Polymeric adducts based on dextran, poly(ethylene glycol) or poly(N-vinyl pyrrolidone), and aliphatic esters with alkyl chain-lengths greater than 7 are inactive in potentiation. Derivatives containing carboxyl groups are also inactive. Potentiation is discussed in terms of platelet membrane penetration and extra- and intra-cellular processes. The latter are invoked to account for the enhanced potentiation shown by dipyridamole and derivatives when aggregation is induced by PAF-acether rather than ADP. One derivative of particular interest is the adduct of theophylline with 1,2,5,6-diisopropylidene-D-glucose, containing a furanose ring. This is a more active potentiator than theophylline itself, possibly owing to its molecular resemblance to cAMP. On conversion to the pyranose form all activity is removed.
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