In vivo Secretion of LHRH in Ovariectomized Rats Is Regulated by a Possible Autofeedback Mechanism
作者:
Dipak Kumar Sarkar,
期刊:
Neuroendocrinology
(Karger Available online 1987)
卷期:
Volume 45,
issue 6
页码: 510-513
ISSN:0028-3835
年代: 1987
DOI:10.1159/000124783
出版商: S. Karger AG
关键词: LHRH secretion;Pituitary portal blood;Autofeedback;LHRH analogs;LH secretion Saffan anesthesia;Ovariectomized rats
数据来源: Karger
摘要:
An episodic secretion of LHRH in pituitary portal blood was observed in ovariectomized and hypophysectomized rats under Saffan anesthesia. This anesthetic did not effect the pulsatile release of LH in ovariectomized rats. Third-ventricular administration of an LHRH agonist, at a concentration which did not cross-react in the LHRH RIA, suppressed both the pulse amplitude and frequency of LHRH release. This inhibitory action of the LHRH agonist on LHRH release was blocked by an LHRH antagonist.
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