Massive Splenomegaly and Epstein‐Barr Virus‐Associated Infectious Mononucleosis in a Patient With Gaucher Disease
作者:
Mary Eapen,
Margaret Hostetter,
Joseph Neglia,
期刊:
Journal of Pediatric Hematology/Oncology
(OVID Available online 1999)
卷期:
Volume 21,
issue 1
页码: 47-49
ISSN:1077-4114
年代: 1999
出版商: OVID
关键词: Massive splenomegaly;Infectious mononucleosis;Gaucher disease.
数据来源: OVID
摘要:
Purpose: Gaucher disease should be considered in the differential diagnosis of a patient with Epstein-Barr virus (EBV) infection who has unexplained or disproportionate splenomegaly.Patients and Methods: A previously asymptomatic adolescent with EBV-associated infectious mononucleosis and massive splenomegaly is described. He was found to have Gaucher disease on bone marrow biopsy, which was performed to exclude a hematologic malignancy. The diagnosis was confirmed by assay of β-glucosidase enzyme activity.Results: Regression of splenomegaly and improving hematologic indices.Conclusion: Patients with infectious mononucleosis and disproportionate organomegaly should be investigated to exclude a hematologic malignancy or an underlying storage disorder such as Gaucher disease.
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