In this paper we present a general-purpose analytical model to compute die approximate throughput capacity of a trip-based material handling system used in a manufacturing setting. A wide variety of handling systems, including freight elevators, cranes, microload automated storage/retrieval (AS/R) systems, industrial lift trucks, and automated guided vehicle (AGV) systems can be modeled as trip-based handling systems. To our knowledge, this model is one of the few analytical models that explicitly considers an empty device dispatching rule. The model is first developed for a single-device system (such as a crane) and subsequently, with a simple modification, it is extended to multiple-device systems (such as lift trucks and AGVs). Using this model one can rapidly evaluate a wide range of handling and layout alternatives for given flow data. Hence, die model would be most effective when used early in the design phase to narrow down die set of alternative handling systems and configurations prior to simulation.