首页   按字顺浏览 期刊浏览 卷期浏览 Evaluation of Clinical and Histological Prognostic Markers in Drug-Induced Acute Inters...
Evaluation of Clinical and Histological Prognostic Markers in Drug-Induced Acute Interstitial Nephritis

 

作者: BhaumikS. K.,   KherVijay,   AroraPradeep,   RaiPradeep K.,   SinghalManoj,   GuptaAmit,   PandeyR.,   SharmaRaj K.,  

 

期刊: Renal Failure  (Taylor Available online 1996)
卷期: Volume 18, issue 1  

页码: 97-104

 

ISSN:0886-022X

 

年代: 1996

 

DOI:10.3109/08860229609052779

 

出版商: Taylor&Francis

 

关键词: Acute renal failure;Interstitial nephritis;Renal recovery;Steroid therapy

 

数据来源: Taylor

 

摘要:

We analyzed the case records of 19 patients diagnosed to have drug-induced acute interstitial nephritis to assess the clinical profile and role of steroids in renal recovery, and to correlate histological features to outcome. Patients with underlying glomerular diseases, malignancy, obstructive nephropathy, or systemic infections were excluded. Nonsteroidal anti-inflammatory drugs alone accounted for 6 cases (group A), whereas antibiotics were the major offender in the remaining patients (group B). In 13/19 (69%) cases, renal failure was severe enough to require dialytic support. Overall 14/19 (74%) of the patients recovered normal renal function within 6 weeks of withdrawal of the offending drugs. Neither the extent of renal recovery nor the time required for it was altered by oral steroids. Tubular atrophy and interstitial fibrosis adversely affected renal recovery. Oliguria, tubular necrosis, interstitial edema, and the density/distribution of interstitial infiltrate did not have any effect on the rate/ extent of renal recovery.

 

点击下载:  PDF (480KB)



返 回