Modulation of Platelet Function by Prostaglandins: Characterization of Platelet Receptors for Stimulatory Prostaglandins and the Role of Arachidonate Metabolites in Platelet Degranulation Responses
作者:
Euan MacIntyre,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1979)
卷期:
Volume 8,
issue 3-5
页码: 274-293
ISSN:1424-8832
年代: 1979
DOI:10.1159/000214318
出版商: S. Karger AG
关键词: Platelets;Prostaglandins;Prostaglandin receptors;Degranulation
数据来源: Karger
摘要:
The effects of PGG2 and PGH2 on platelets are mimicked by synthetic PG analogues in which the nature and specificity of the substituents on carbons 11 and 15 (or 16) are important determinants of reactivity. Arachidonic acid and stimulatory PGs induce secretion of platelet dense granule and alpha granule constituents, but not lysomal constituents, although arachidonate metabolism is necessary for collagen-induced release of lysosomal enzymes. N0164 acts on platelets as an endoperoxide antagonist: Trimethoquinol acts as an endoperoxide and TxA2 antagonist. PGs induce platelet aggregation by combining with a specific (endoperoxide) receptor.
点击下载:
PDF
(4608KB)
返 回