Creatol, a Creatinine Metabolite, as a Useful Determinant of Renal Function
作者:
Ko Nakamura,
Kazuharu Ienaga,
Koji Nakano,
Masahiko Nakai,
Yoshio Nakamura,
Goji Hasegawa,
Manabu Sawada,
Motoharu Kondo,
Hiroshi Mori,
Takahiro Kanatsuna,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 66,
issue 2
页码: 140-146
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187791
出版商: S. Karger AG
关键词: Creatol;Creatinine;Chronic renal failure;Oxygen stress
数据来源: Karger
摘要:
Analysis of creatoi (CTL, 5-hydroxycreatinine), an oxidative creatinine (Cr) metabolite, in serum and urine of human subjects has indicated that CTL is a useful determinant of renal function. The existence itself of serum CTL (s-CTL) could be a diagnostic sign for chronic renal failure (CRF): in all normal subjects, s-CTL was undetectable, but s-CTL was detectable in sera of all patients with CRF (s-Cr: > 2.0 mg/dl). And the s-CTL values increased in proportion to the severity of CRF in such patients. Furthermore, the molar ratio (CTL/Cr) in both urine and serum increased significantly in proportion to the severity of CRF. Our results indicated not only hyperproduction of CTL but also higher oxygen stress in patients according to the progression of CRF. The diagnostic importance of the CTL value and the CTL/Cr ratio are discussed.
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