The Analysis of Theophylline — Containing Pharmaceuticals by Room Temperature Phosphorescence
作者:
RickyP. Bateh,
JamesD. Winefordner,
期刊:
Analytical Letters
(Taylor Available online 1982)
卷期:
Volume 15,
issue 4
页码: 373-383
ISSN:0003-2719
年代: 1982
DOI:10.1080/00032718208064389
出版商: Taylor & Francis Group
关键词: Theophylline — capsule;elixir;syrup;tablet;Room temperature phosphorescence analysis — aminophylline;dyphylline;oxtriphylline;theophylline
数据来源: Taylor
摘要:
A simple and specific technique is used in analyzing pharmaceutical preparations (capsules, elixirs, syrups, and tablets) for theophylline and related compounds. The procedure consists of dissolving (diluting) appropriate amounts of the preparations and standards in (with) a 1 M KI-water solution, spotting 5 μL of each resultant solution onto filter paper discs, determining the phosphorescence intensities at room temperature and comparing sample signal levels to those of standards. The quantities of active ingredients and standards used in the determinations ranged from 25 ng to 1 μg. The results indicate that room temperature phosphorescence is useful for analyzing pharmaceutical preparations where active ingredients are usually contained in a wide variety of matrices.
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