Aminoglycoside Dosing in Pediatric Patients
作者:
Bruce,
Carlstedt Mana,
Uaamnuichai R,
Day Lee,
Bowman D,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 1
页码: 38-43
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Pharmacokinetics;Pediatrics;Aminoglycoside antibiotics;Bayesian feedback.
数据来源: OVID
摘要:
We assessed the performance of a predictive algorithm for dosing aminoglycoside antibiotics in 75 pediatric patients and Bayesian feedback in 36. The absolute errors for peak and trough concentrations were 1.83 and 0.80 mUg/ml, respectively, which seem clinically acceptable for most patients. However, the algorithm had significant negative bias for both peaks and troughs. Implementation of Bayesian feedback eliminated bias in a second set of concentrations and significantly decreased its magnitude for both peaks (p= 0.028) and troughs (p= 0.005). This method may allow more accurate dosing of aminoglycoside antibiotics in pediatric patients, though it would most likely be improved by better definition of population parameters and their variability.
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