Different Technetium Complexes with Mercaptoacetyltriglycine
作者:
B. Johannsen,
B. Noll,
K.-H. Heise,
K. May,
H. Spies,
I. Hoffmann,
St. Hoffmann,
D. Klötzer,
H. Reiβ,
L. Bruch,
D. Modersohn,
期刊:
Isotopenpraxis Isotopes in Environmental and Health Studies
(Taylor Available online 1990)
卷期:
Volume 26,
issue 3
页码: 97-101
ISSN:0021-1915
年代: 1990
DOI:10.1080/10256019008624241
出版商: Taylor & Francis Group
关键词: complexes;nuclear medicine;radiopharmaceuticals;technetium compounds;technetium 99;technetium 99m
数据来源: Taylor
摘要:
Syntheses performed with unprotected mercaptoacetylglycylglycylglycine (MAG3) both at carrier level (10−4M) and with no-carrier-added99mTc indicated that various products of different biological properties exist in the Tc/MAG3 system. Besides the known Tc(V)oxo complex recently introduced into nuclear medicine for renal function diagnosis, mainly three species were characterized by HPLC, TLC, electrophoresis and uv-vis spectroscopy as well as biodistribution studies in minipigs. Alteration of preparation conditions such as concentrations, sequence of reactant addition, pH, and time enabled to elucidate reaction routes within the system, interdependence of the species, and vulnerability of the kidney imaging agent.
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