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Tritium labeling of potential lipophilic myelin probes

 

作者: R. L. E. Ehrenkaufer,   B. W. Agranoff,   J. Bieszki,   K. Frey,   S. Hays,   D. Jewett,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1984）
卷期: Volume 21, issue 1  

页码: 87-95

 

ISSN:0362-4803

 

年代: 1984

 

DOI:10.1002/jlcr.2580210110

 

出版商: John Wiley&Sons, Ltd.

 

关键词: Tritium labeling;Exchange labeling;Microwave discharge labeling;Myelin;Positron Emission Tomography

 

数据来源: WILEY

 

摘要:

AbstractTwo potential lipophilic myelin imaging agents (1,1,2,2‐tetrafluoro‐1,2‐diphenylethane and 1‐fluoroadamantane) were tritium labeled. The most effective method employed the microwave discharge activation of tritium gas technique and resulted in specific activities of 177 mCi/mmol for 1,1,2,2‐tetrafluoro‐1,2‐diphenylethane and 593 mCi/mmol for 1‐fluoroadamantane. Using this tritiation method significant amounts of tritium‐for‐fluorine substitution was also observed in the labeling of 1‐fluoroadamatane, resulting in nearly equivalent amounts of tritiated adamantane

 

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