In a previous study Beckman and Beckman [Hum. Hered. 1986;36:254-255] reported a decrease in the Tf C2 frequency with age, from 0.173 in newborns to 0.099 in 70-year-old healthy individuals. The authors suggested a selective disadvantage for Tf C2. In a population from Leipzig (FRG) older people have the highest C2 gene frequency (0.1701 vs. 0.1629 in children < 5 years). The differences are not significant. A dependency of C2 frequency on age seems to remain in question.