Modulation of transcription in rat liver nuclei in vitro by a diol epoxide of benzo[a]pyrene
作者:
G. M. Shah,
R. K. Bhattacharya,
期刊:
Journal of Biochemical Toxicology
(WILEY Available online 1992)
卷期:
Volume 7,
issue 1
页码: 13-17
ISSN:0887-2082
年代: 1992
DOI:10.1002/jbt.2570070104
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: 7β;8α‐Dihydroxy‐9α;10α‐Epoxy‐7,8,9,10‐Tetrahydrobenzo[a]pyrene;Nuclear Transcription;Chromatin;RNA Polymerases
数据来源: WILEY
摘要:
AbstractTreatment of isolated rat liver nuclei with 7β, 8α‐dihydroxy‐9α, 10α‐epoxy‐7, 8, 9, 10‐tetrahy‐drobenzo[a]pyrene, the ultimate carcinogenic metabolite of benzo[a]pyrene, resulted in inhibition of transcription as measured by radioactive precursor incorporation into RNA. The mechanism of inhibition as analyzed by use of different types of inhibitors suggested that the carcinogen acted on both the major components of transcription machinery, that is, the template chromatin and the enzyme RNA polymerases. This action correlates well with the observations made after administration of benzo[a
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