Treatment of Relapsing and Refractory Adult Acute Myeloid Leukemia According toin vitroClonogenic Leukemic Cell Drug Sensitivity
作者:
DelmerAlain,
PierreJean,
TheveninDanielle,
MarieAnne,
ZittounRobert,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 10,
issue 1-2
页码: 67-71
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309147358
出版商: Taylor&Francis
关键词: Acute myeloid leukemia;clonogenic assay;drug sensitivity;chemotherapy
数据来源: Taylor
摘要:
In an attempt to improve the results of treatment in patients with relapsing or refractory acute myeloid leukemia (AML), we conducted a pilot study using a two-drug salvage regimen according to thein vitroclonogenic leukemic cell (CFU-L) drug sensitivity. Fourteen patients were included in the study, 10 with relapsing and 4 with refractory AML. Drug exposure was assessed for daunorubicin, cytosine arabinoside, etoposide, mitoxantrone and amsacrine. The two drugs with the best inhibitory effect on CFU-L were selected for the treatment. A complete remission was achieved in only 4 patients and a partial remission in 3 patients. Although the number of patients is too small for appropriate statistical analysis and for a definite conclusion to be drawn, the observed response rate with directed therapy did not appear better than that expected from empiric salvage regimen.
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