Alcohol Dehydrogenase in the Human Colon and Rectum
作者:
Helmut K. Seitz,
Gerlinde Egerer,
Carl Oneta,
Silke Krämer,
Andreas Sieg,
Fritz Klee,
Ulrich A. Simanowski,
期刊:
Digestion
(Karger Available online 1996)
卷期:
Volume 57,
issue 2
页码: 105-108
ISSN:0012-2823
年代: 1996
DOI:10.1159/000201322
出版商: S. Karger AG
关键词: Alcohol dehydrogenase;Colorectum;Carcinogenesis;Age
数据来源: Karger
摘要:
Alcohol dehydrogenase (ADH) activities were measured in rectal biopsies from 55 patients (28 males, 27 females aged 22-81 years), in colonic biopsies from 19 patients (10 males, 9 females aged 21-81 years) and in three surgical specimens. All patients had normal mucosa as determined by light microscopy. The activity of rectal ADH was comparable to gastric ADH activity and did not exhibit any significant gender effect (5.5 ± 1.1 vs. 6.7 ± 1.0 nmol/mg protein × min; nonsignificant). No significant correlation was found between age and rectal ADH activity. Compared to ADH activities in other colonic segments, rectal ADH activity was found to be significantly increased (ascending colon: 3.9 ± 0.7 nmol/mg protein × min; p < 0.05; transversal colon: 3.4 ± 1.1 nmol/mg protein × min; p < 0.05; descending colon 2.3 ± 0.4 nmol/mg protein × min; p < 0.001; rectum 6.1 ± 0.8 nmol/mg protein × min). This higher activity of ADH in the rectum could result in increased acetaldehyde levels after alcohol administration and could therefore play a role, at least in part, in the ethanol-associated rectal cocarc
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