Effects of haloperidol and d-amphetamine on working and reference memory performance in a spatial cone field task
作者:
A Blokland,
W Honig,
J Prickaerts,
期刊:
Behavioural Pharmacology
(OVID Available online 1998)
卷期:
Volume 9,
issue 5
页码: 429-436
ISSN:0955-8810
年代: 1998
出版商: OVID
关键词: spatial;working memory;reference memory;arousal;haloperidol;d-amphetamine;rat
数据来源: OVID
摘要:
The present study was designed to examine the effects of haloperidol (0.03, 0.1 mg/kg, intraperitoneal (i.p.)) and damphetamine (0.3, 1.0 mg/kg, i.p.) in a cone field task in which spatial working and reference memory (WM and RM, respectively) were assessed simultaneously. The apparatus is a large open field in which 16 cones are placed with four cones baited by placing a food reward in the top. After food-deprived rats had acquired this task they showed a high level of performance, that is avoided visits to non-baited cones (RM) and made few revisits to baited cones (WM). Haloperidol had a greater negative effect on RM than on WM performance, but also decreased the number of food rewards collected. On the other hand, the high dose of (damphetamine induced a clear WM performance deficit, whereas RM performance was only marginally affected. The present study suggests that spatial discrimination performance can be dissociated using the measures RM and WM in the present task. Further, the deficits induced by haloperidol and (damphetamine may not be specifically related with impaired mnemonic functions.
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