Medial nigral dopamine neurons have rich neurotrophin support in humans
作者:
Takeshi Nishio,
Shoei Furukawa,
Ichiro Akiguchi,
Nobuhiko Sunohara,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2847-2851
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Autocrine/paracrine;BDNF;Dopamine;Immunohistochemistry;Neurotrophins;NGF;NT-3;Parkinson's disease;Substantia nigra;trk
数据来源: OVID
摘要:
To assess the action of neurotrophin in human dopaminergic neurons, we studied the immunolocalization of neurotrophins or trks in human substantia nigra pars compacta (SNc). The neuromelanin-containing neurons in the SNc showed immunoreactivities for neurotrophins or trks, suggesting an autocrine/ paracrine regulation. Quantitative analysis revealed that the percentage of those expressing NGF-like immunoreactivity (NGF-LI), BDNF-LI, NT3-LI, trkALI, trkB-LI, or trkC-LI was 66%, 74%, 85%, 66%, 71% or 86%, respectively. The percentage of cells expressing neurotrophins or trks was higher in the medial part than in the lateral part of the SNc. The preferential expression of neurotrophin-trk systems in the medial neurons may, at least partially, explain the differential susceptibility in Parkinson's disease
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