Vitamin K-Dependent Processes in Tumor Cells
作者:
Peter V. Hauschka,
Yacoob Haroon,
Stephen D. Buchthal,
Robert G. Bell,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1986)
卷期:
Volume 16,
issue 3-4
页码: 273-287
ISSN:1424-8832
年代: 1986
DOI:10.1159/000215299
出版商: S. Karger AG
关键词: Vitamin K;Protein carboxylase;Gamma-carboxyglutamic acid;Blood coagulation;Coumarin anticoagulants;Tumor cells;Cathepsin B
数据来源: Karger
摘要:
Tumor cells are known to interfere with blood coagulation pathways of the host by producing procoagulants and other substances, thereby deriving certain advantages relating to tumor growth, metastasis, and angiogenesis. Anticoagulants may diminish these advantages under certain conditions. The interaction between coumarin anticoagulants and tumor cells has been reviewed with respect to procoagulants and their vitamin K-dependent properties. Evidence is also presented which suggests that vitamin K-dependent protein carboxylation is a general property of tumor cells.
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