Short CAG repeats within thehSKCa3gene associated with schizophreniaresults of a family‐based study
作者:
Gerald Stöber,
Susanne Jatzke,
Jobst Meyer,
Olga Okladnova,
Michael Knapp,
Helmut Beckmann,
Klaus-Peter Lesch,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 16
页码: 3595-3599
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Association study;Genetics;hSKCa3;Linkage;Schizophrenia;Trinucleotide repeat
数据来源: OVID
摘要:
IN a family-based association study we investigated transmission of a multiallelic CAG repeat in a novel neuronal potassium channel gene,hSKCa3, in 59 parent/ offspring trios. In contrast to recent reports of an association of moderately large repeats with schizophrenia in case-control studies, our findings indicate that short CAG repeats (≤ 19 repeats) are transmitted at an increased frequency to schizophrenic offspring (p= 0.014), particularly among familial cases (p= 0.007). No evidence for a parent-of-origin effect was found. Multiallelic TDT procedure showed no association of individual CAG repeats to schizophrenia. Further studies using family-based designs should clarify whetherhSKCa3is a susceptibility factor to schizophrenia or co-segregates with a major disease gene in tight linkage.
点击下载:
PDF
(353KB)
返 回