Immunological and Trophical Effects ofSaccharomycesboulardiion the Small Intestine in Healthy Human Volunteers
作者:
Hans-Ulrich Jahn,
Reiner Ullrich,
Thomas Schneider,
Ralf-Marco Liehr,
Henrike L. Schieferdecker,
Hasso Holst,
Martin Zeitz,
期刊:
Digestion
(Karger Available online 1996)
卷期:
Volume 57,
issue 2
页码: 95-104
ISSN:0012-2823
年代: 1996
DOI:10.1159/000201320
出版商: S. Karger AG
关键词: Saccharomyces boulardii;Diarrhea;Immunology;Mucosa-associated immune system;Small intestine;Lymphocytes;Enterocytes;Enzyme activity
数据来源: Karger
摘要:
Saccharomyces boulardii (S.b.) is used for the prevention and treatment of diarrhea of different etiologies. We prospectively investigated the effects of S.b. on lymphocytes and duodenal mucosa. Before and after oral administration of S.b. for 3 weeks, circulating and intestinal lymphocytes were isolated and characterized by flow cytometry. Trophic effects on duodenal mucosa were investigated by morphometry and determination of brush border enzyme activity. Results were compared intraindividually before and after S.b. In intestinal lymphocytes no phenotypic changes were observed. CD4+ cells of the peripheral blood had a significantly increased expression of CD25 (p < 0.02). None of twelve volunteers had an increase in villous surface area (n.s.). Immunoglobulin A content in small intestine secretion was unaltered. An increase in brush border enzyme activity of lactase, α-glucosidase, and alkaline phosphatase was observed (p < 0.01). Our findings indicate that S.b. has a positive effect on the maturation of enterocytes and only a minor influence on lymphocytes
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