Regulation of antioxidant enzyme expression in LPS-treated bovine retinal pigment epithelial and corneal endothelial cells
作者:
Del VecchioPeter J.,
ShafferJacquelin B.,
期刊:
Current Eye Research
(Taylor Available online 1991)
卷期:
Volume 10,
issue 10
页码: 919-925
ISSN:0271-3683
年代: 1991
DOI:10.3109/02713689109020327
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Retinal pigment epithelial (RPE) and corneal endothelial (CE) cells, because of their locations and functions, are continuously exposed to toxic oxidants. Protection from these toxic materials may be due, in part, to the action of endogenous antioxidant enzymes. We have established the presence of mRNAs that encode antioxidant enzymes in bovine RPE and CE cells and have determined the effect of bacterial lipopolysaccharide (LPS) on their expression. The most striking change in antioxidant enzyme expression is an increase in the level of mitochondrial manganous superoxide dismutase (MnSOD) mRNA in the LPS-treated RPE and CE cells. This increase in mRNA expression is accompanied by a slight increase in MnSOD activity as determined by SOD activity gels.
点击下载:
PDF (514KB)
返 回