Increased Erythrocyte Adenosine Deaminase Activity without Haemolytic Anaemia
作者:
G. Novelli,
V. Stocchi,
A. Giannotti,
M. Magnani,
B. Dallapiccola,
期刊:
Human Heredity
(Karger Available online 1986)
卷期:
Volume 36,
issue 1
页码: 37-40
ISSN:0001-5652
年代: 1986
DOI:10.1159/000153597
出版商: S. Karger AG
关键词: Adenosine deaminase;Haemolytic anaemia;Adenosine-5’-triphosphate
数据来源: Karger
摘要:
A 4-fold increase of red blood cell adenosine deaminase (ADA) activity was found in a patient without haemolytic anaemia, but with mild anisopoikilocytosis. High-performance liquid chromatography showed a 40% reduction of adenosine-5’-triphosphate (ATP) while all the other nucleotides were in normal ranges. The patient’s parents (first cousins) and a brother displayed the same enzyme activities as the controls. This observation suggests that mild increases of ADA activity is neither a marker for congenital hypoplastic anaemia as previously reported nor associated with haemolytic anae
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