Quantitative Anti‐p24 Determinations Can Predict the Risk of Vertical Transmission
作者:
P. Erb,
S. Krauchi,
D. Burgin,
K. Biedermann,
C. Camli,
Ch. Rudin,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1994)
卷期:
Volume 7,
issue 3
页码: 261-264
ISSN:0894-9255
年代: 1994
出版商: OVID
关键词: HIV-1;Vertical transmission;Quantitative anti-p24;CD4 count;Neopterin;Beta-2 microglobulin;Virus isolation.
数据来源: OVID
摘要:
SummaryQuantitative serum antibody to p24 was evaluated as a predictor of risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) infection. HIV-positive mothers, 13 with HIV-infected children and 24 with noninfected children were investigated during pregnancy and at the time of delivery. A statistically significant difference in anti-p24 titers was found between the mothers with infected and those with noninfected children independent of whether antibodies were measured during pregnancy or at the time of delivery. High anti-p24 levels correlated with a low risk of vertical transmission, whereas low anti-p24 titers were associated with an increased risk of vertical transmission. Although the number of CD4+T-cells was lower and neopterin and beta-2 microglobulin values were higher in the group of mothers with infected children than in the noninfected group, no statistical significance was achieved due to the small sample size.
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