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Novel alternative splicing in the 5′ exon of the neurotrophin‐3 gene

 

作者: Masashi Sekimoto,   Katsumi Fukamachi,   Fumiko Nemoto,   Shingo Miyata,   Masakuni Degawa,   Emiko Senba,   Takashi Ueyama,   Kiyomitsu Nemoto,  

 

期刊: NeuroReport  （OVID Available online 1998）
卷期: Volume 9, issue 16  

页码: 3675-3679

 

ISSN:0959-4965

 

年代: 1998

 

出版商: OVID

 

关键词: Alternative splicing;Expression;mRNA;Nucleotide sequence;Neurotrophin-3;Neurotrophin factor

 

数据来源: OVID

 

摘要:

THE neurotrophin-3 (NT-3) gene has previously been reported to consist of three exons including two 5′ short untranslated exons and a 3′ long exon encoding the entire protein, and to give rise to two classes of transcripts by alternative splicing of the 5′ exons to the 3′ coding exon. In the present study, we demonstrated the presence of at least four new classes of transcripts of the NT-3 gene, in addition to the two known transcripts. The present finding proposes the further complexity of the regulational mechanism for NT-3 expression.

 

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