Serotonin as a mediator of cyclic flow variations in stenosed canine coronary arteries
作者:
JULIET ASHTON,
CLAUDE BENEDICT,
CHARLES FITZGERALD,
SURESH RAHEJA,
ANNE TAYLOR,
WILLIAM CAMPBELL,
L. BUJA,
JAMES WILLERSON,
期刊:
Circulation
(OVID Available online 1986)
卷期:
Volume 73,
issue 3
页码: 572-578
ISSN:0009-7322
年代: 1986
出版商: OVID
数据来源: OVID
摘要:
The data obtained in this study demonstrate that the concentration of serotonin is markedly elevated (18- to 27-fold) at the site of a coronary arterial stenosis in open-chest, anesthetized dogs with cyclic flow variations. Cyclic flow variations in this experimental preparation were abolished by ketanserin, a 5-hydroxytryptamine antagonist, but serotonin concentration at the site of the coronary stenosis remained elevated. The intra-atrial administration of serotonin (0.16 to 1 mg/min) restored cyclic flow variations after they had been abolished by ketanserin. Taken together, these data suggest that serotonin may be one of the important mediators of cyclic flow variations in this experimental preparation.
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