首页   按字顺浏览 期刊浏览 卷期浏览 Prolonged Δ4‐Cholestenone Feeding in BirdsThe Effects on Plasma and Liver ...
Prolonged Δ4‐Cholestenone Feeding in BirdsThe Effects on Plasma and Liver Sterols and the Induction of Aortic Arteriosclerosis

 

作者: C. Nichols,   S. Lindsay,   D. Chapman,   I. Chaikoff,  

 

期刊: Circulation Research  (OVID Available online 1960)
卷期: Volume 8, issue 1  

页码: 16-28

 

ISSN:0009-7330

 

年代: 1960

 

出版商: OVID

 

数据来源: OVID

 

摘要:

The pathologic changes in the aorta, liver, and adrenal glands, and the changes in sterols of plasma and liver induced in birds by the prolonged feeding of a diet containing 0.5 per cent Δ4-cholestenone are described. Lesions were found in the media of thoracic aortas and intima of the abdominal aortas of the sterol-fed birds and evidence is presented to show that the crystalline material in the abdominal plaques is not cholesterol. There was enlargement of both liver and adrenal glands with a pronounced deposition of total digitonin-precipitable sterols which could not be accounted for by Liebermann-Burchard reacting sterols (LBRS). In the Δ4-cholestenone-fed birds the level of LBRS in plasma, fell to about 50 per cent of that in control birds, whereas the levels of total digitonin-precipitable sterols (TDPS) rose to values of 200 mg. per 100 ml. The fraction of the TDPS present as non-LBRS was quite constant in the plasma of the sterol-fed birds (63–69 per cent). By means of isotope dilution procedures the non-LBRS in the livers of sterol-fed birds was identified as dihydrocholesterol.

 

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