Evaluation of the genetic activity of industrially produced carbon black
作者:
C. J. Kirwin,
J. V. LeBlanc,
W. C. Thomas,
S. R. Haworth,
P. E. Kirby,
A. Thilagar,
J. T. Bowman,
D. J. Brusick,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1981)
卷期:
Volume 7,
issue 6
页码: 973-989
ISSN:0098-4108
年代: 1981
DOI:10.1080/15287398109530039
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Commercially produced oil furnace carbon black (Chemical Abstract Service Registry No. 1333–86–4) has been evaluated by five different assay for genetic activity. These were the AmesSalmonella typhimuriumreverse mutation test, sister chromatid exchange test in CHO cells, mouse lymphoma test, cell transformation assay in C3H/10T1/2 cells, and assay for genetic effects inDrosophila melanogaster. Limited cellular toxicity was exhibited but no significant genetic activity was noted.
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