Dopamine and serotonin VMN release is related to feeding status in obese and lean Zucker rats
作者:
Michael Meguid,
Sergueï Fetissov,
Vladimir Blaha,
Zhong-Jin Yang,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 10
页码: 2069-2072
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: Autonomic regulation;Food intake;Hypothalamus;Obesity
数据来源: OVID
摘要:
Study of neurotransmitter role in food intake regulation in a leptin signaling deficient model, such as the Zucker rat, would benefit in the understanding of mechanisms of human obesity, in which leptin resistance is a common syndrome. We studied dopamine (DA) and serotonin (5-HT) concentrationsin vivoin the ventromedial nucleus (VMN) of the hypothalamus, as they relate to eating after food deprivation in obese and lean 9-week-old male Zucker rats. DA and 5-HT concentrations were measured by HPLC via microdialysis before and during refeeding in 24-h food-deprived rats. Before food was provided, mean baseline DA and 5-HT levels were lower in obese than in lean rats (9.2 ± 0.9vs15.1 ± 1.9 pg/10 μl,p< 0.01, and 0.68 ± 0.05vs1.17 ± 0.02 pg/10 μl,p< 0.001, respectively). Food intake was accompanied by a decrease in DA levels in both obese and lean rats to 64% (p< 0.01) and 65% (p< 0.02) of their baseline levels respectively. 5-HT levels were significantly increased during eating by 41% in obese and 35% in lean rats (p< 0.01) from the baseline levels. Thus in obese rats with altered leptin signaling we found an unaltered pattern of DA and 5-HT release associated with food deprivation and refeeding, but with presence of their low levels. This points to an impaired postsynaptic monoaminergic action to produce an adequate metabolic response in obese Zucker rats in response to feeding state.
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