Gastrointestinal Uses of Botulinum Toxin
作者:
Waqar Qureshi,
期刊:
Journal of Clinical Gastroenterology
(OVID Available online 2002)
卷期:
Volume 34,
issue 2
页码: 126-128
ISSN:0192-0790
年代: 2002
出版商: OVID
关键词: Botulinum toxin;Achalasia;Sphincter of Oddi dysfunction;Anal fissure;Anismus.
数据来源: OVID
摘要:
&NA;Botulinum toxin was initially used in medicine to produce a potent neuromuscular blockade. It was later found to interfere with acetylcholine release in the myenteric plexus and inhibit contraction in gastrointestinal smooth muscle, leading to its use in the treatment of various conditions. It is frequently used in the treatment of achalasia in elderly patients who may be poor surgical candidates. It has been used successfully in the management of various conditions, including anal fissure and biliary dyskinesia. Large controlled trials are needed to establish the role of botulinum toxin and its safety in gastroenterology.
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