Effects of 5-Fluorouracil and a Combination of Tegafur and Uracil (UFT) on Nucleotide Metabolism in L1210 Ascites Tumor
作者:
KakitoHideshi,
OhkuboToshiki,
KagawaYoshiyuki,
InagakiShoji,
SumidaKatsumi,
OoiKazuya,
HigashigawaMasamune,
SakuraiMinoru,
期刊:
Cancer Investigation
(Taylor Available online 1993)
卷期:
Volume 11,
issue 5
页码: 530-533
ISSN:0735-7907
年代: 1993
DOI:10.3109/07357909309011671
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Changes in the deoxyribonucleotide pools following a single oral administration of 13 mglkg of 5-fluorouracil (5-FU) or of 64.8 mglkg of UFT (a mixed compound of tegafur and uracil) were investigated. We compared their pharmacodynamics and effects on nucleotide metabolism in L1210 ascites tumor on day 3 after intraperitoneal tumor inoculation. The intracellular dTTP pool decreased to half the control level 1–6 hr after the administration of 5-FU. The dTTP pools rapidly recovered after 6 hr. In contrast, UFT kept the intracellular dTTP level to 1/3 to 1/2 of the control level for 24 hr. Either drug elevated the intracellular dATP pools, but decreased dCTP pools. UFT influenced the intracellular dATP and dCTP levels longer than 5-FU. Orally administered UFT seemed to exert a longer and more potent inhibitory effect on thymidylate synthetase than equimolar 5-FU. In view of these results, we suggest that UFT could be a more potent chemotherapeutic drug than 5-FU in oral administration.
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