Infection following interlocking nailing should be treated in stages. The infection is controlled with suction irrigation or gentamycin polymethyl methacrylate (PMMA) implants and systemic antibiotics. Medullary reaming removes endosteal sequestrae. If the nail is removed before the fracture is united, an external fixateur can be used to immobilize the fracture. The use of a loop drain for continuous suction irrigation and techniques for antibiotic PMMA implants are described. The goal is a healed fracture without recurrence of infection.