Increased Circulating Levels of an Endogenous Digoxin‐Like Factor in Hypertensive Monkeys
作者:
KENNETH GRUBER,
LAWRENCE RUDEL,
BILLY BULLOCK,
期刊:
Hypertension
(OVID Available online 1982)
卷期:
Volume 4,
issue 3
页码: 348-354
ISSN:0194-911X
年代: 1982
出版商: OVID
关键词: digitalis-like factor;natriuretic hormone;sodium-potassium ATPase inhibition
数据来源: OVID
摘要:
An endogenous, immunoreactive digoxin-like factor (endoxin) was measured in the plasma of nonhuman primates with hypertension. Both normotensive and hypertensive rhesus monkeys had levels of endoxin that significantly correlated with their systolic or diastolic blood pressure. Vervet monkeys with experimentally produced chronic Goldblatt hypertension had significantly elevated endoxin, but not plasma renin. These data suggest that increased plasma endoxin may be a contributing factor in the development of hypertension. (Hypertension 4: 348–354, 1982)
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