The HLA System in Italy
作者:
E. Olivetti,
S. Rendine,
N. Cappello,
E.S. Curtoni,
A. Piazza,
期刊:
Human Heredity
(Karger Available online 1986)
卷期:
Volume 36,
issue 6
页码: 357-372
ISSN:0001-5652
年代: 1986
DOI:10.1159/000153660
出版商: S. Karger AG
关键词: HLA;Population study;Italy
数据来源: Karger
摘要:
4,902 Italians were typed for HLA-A antigens, 4,721 for HLA-B and 1,503 for HLA-C. The samples, which were composed of unrelated, healthy individuals born in Italy, were used for estimating HLA-A, HLA-B and HLA-C gene frequencies with the maximum-likelihood method. Different Italian regions showed significant differences in the HLA alleles, providing further evidence for the genetic heterogeneity of the Italian population. HLA gene frequencies place continental Italy and Sicily in a position which is similar to that of other Mediterranean populations, whereas the genetic isolation of Sardinia is quite evident. The most significant linkage disequilibrium values found in the Italian population (except for Sardinia) were in agreement with those observed in other Caucasian populations. The difference between Northern and Southern Italy and between continental Italy and Sardinia was emphasized by the linkage disequilibrium values and by the principal-component analysis as well.
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