Amoxapine Shows an Antipsychotic Effect but Worsens Motor Function in Patients with Parkinson's Disease and Psychosis
作者:
Daniel Sa,
Shitij Kapur,
Anthony Lang,
期刊:
Clinical Neuropharmacology
(OVID Available online 2001)
卷期:
Volume 24,
issue 4
页码: 242-244
ISSN:0362-5664
年代: 2001
出版商: OVID
关键词: Parkinson's disease;Hallucination;Psychosis;Amoxapine;Atypical antipsychotics
数据来源: OVID
摘要:
Amoxapine, a dibenzoxazepine antidepressant, has been suggested to have atypical antipsychotic properties. We tested it to control psychosis in three patients with Parkinson's disease (PD). Two patients had significant improvement in hallucinations, whereas the third could not tolerate the drug for a sufficient period. All three patients experienced a decline in motor function; two also had concomitant reduction in dyskinesias. Therefore, although we found some support for amoxapine having antipsychotic properties, this drug seems to carry a risk of worsening motor function in patients with PD.
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