Mouse cortical neurones lacking APP show normal neurite outgrowth and survival responsesin vitro
作者:
Sarah Harper,
James Bilsland,
Mark Shearman,
Hui Zheng,
Lex Van der Ploeg,
Dalip Sirinathsinghji,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 13
页码: 3053-3058
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Amyloid-β;Amyloid precursor protein;Cortical neurone;Neurite outgrowth
数据来源: OVID
摘要:
WE have cultured neurones from the developing cortex of mice that have had the amyloid precursor protein gene deleted (APP-null). Neurones cultured for a period of 24 h show similar neurite outgrowth and survival responses to wild-type neurones. Similar neurite outgrowth responses were also seen when neurones from APP-null mice were treated with a neurotrophic peptide derived from the APP sequence and compared with wild-type neurones. Finally, cortical cultures derived from APP-null mice showed similar survival responses to the toxic amyloid-β peptide.
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