The Behaviour of Suppressor-Inducer T Cells Following Treatment for Graves' Disease
作者:
WilsonR.,
PearsonC.,
McKillopJ. H.,
BurnettA. K.,
ThomsonJ. A.,
期刊:
Autoimmunity
(Taylor Available online 1990)
卷期:
Volume 6,
issue 1-2
页码: 93-97
ISSN:0891-6934
年代: 1990
DOI:10.3109/08916939008993373
出版商: Taylor&Francis
关键词: Suppressor - inducer T cells;Graves' disease
数据来源: Taylor
摘要:
The expression of surface markers of T cell subsets in the peripheral blood of 30 Graves' disease patients was investigated pre and post therapy using two colour flow cytometry. Reduced numbers of total, helper/inducer and suppressor/cytotoxic T cells were found in untreated Graves' patients. Numbers of suppressor-inducer T cells which are associated with maintaining the normal immune response, did not differ significantly between untreated Graves' patients and controls. Although 8 weeks' Carbimazole therapy reversed the changes in total, helper/inducer and suppressor/cytotoxic T cells, PTU or131I therapy did not. While suppressor-inducer T cell numbers were not affected by Carbimazole or PTU therapy,l31I treatment caused a decrease in suppressor-inducer T cell numbers.
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