CCK‐8 inhibits ingestive behavior in rats with lateral hypothalamic 6‐OHDA lesions
作者:
M Qian,
A Johnson,
P Södersten,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2763-2767
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cholecystokinin;Dopamine;Food intake;6-Hydroxydopamine;Male rats
数据来源: OVID
摘要:
MALE rats were injected with 6-hydroxydopamine in the lateral hypothalamus and tested for ingestive behavior starting on the day after the injection. The rats did not eat food pellets but readily ingested an intraorally infused nutritive solution. If given three daily intraoral infusions, 6-hydroxydopamine-treated rats defended their body weight and were as sensitive to the inhibitory effect of cholecystokinin octapeptide on intake as controls. Dopamine was reduced by 94% in the dorsal striatum five days after the 6-hydroxydopamine injection. Noradrenaline and serotonin were less markedly affected. Thus, while appetitive ingestive behavior is disrupted, consummatory ingestive behavior and body weight regulatory competence are only marginally affected by massive damage to forebrain dopamine neural networks
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