AMPA and NMDA receptor‐dependent spinal LTP after nociceptive tetanic stimulation
作者:
Frode Svendsen,
Arne Tjølsen,
Kjell Hole,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 6
页码: 1185-1190
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: D-AP5;Long-term potentiation;NBQX;Neuronal plasticity;Pain;Spinal dorsal horn;Wide dynamic range neuron
数据来源: OVID
摘要:
LTP is often studied as a model of synaptic plasticity. Plasticity in pain control systems may involve mechanisms similar to those involved in learning. We recently reported LTP of both the Aβ and C-fibre evoked responses of single dorsal horn neurons after a tetanic stimulation of the sciatic nerve, lasting for at least 6 h. In the present paper we show that identical stimulation induced LTP only of the C-fibre evoked response after blockade of muscular contractions during the tetanus. The C-fibre evoked response increased significantly less after pretreatment with either the AMPA antagonist NBQX or the NMDA antagonist D-AP5 (mean increase 33%) than in untreated animals (105%,p< 0.001), indicating that both AMPA and NMDA receptor stimulation are involved in the induction of LTP.
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