Consequence of Dynorphin-A Administration on Anterior Pituitary Hormone Concentrations in the Adult Male Rhesus Monkey
作者:
Pamela M. Gilbeau,
Yoshio Hosobuchi,
Nancy M. Lee,
期刊:
Neuroendocrinology
(Karger Available online 1987)
卷期:
Volume 45,
issue 4
页码: 284-289
ISSN:0028-3835
年代: 1987
DOI:10.1159/000124742
出版商: S. Karger AG
关键词: Dynorphin-A(l-13);Dynorphin-A(l-10)-amide;Prolactin;Luteinizing hormone;Follicle-stimulating hormone;Thyrotropin;Growth hormone;Monkey
数据来源: Karger
摘要:
This study examines the role of dynorphin-A(1-13) and dynorphin-A(1-10)-amide in the neuroendocrine regulation of anterior pituitary hormones in nonrestrained, adult male rhesus monkeys. The effects of these opioids on plasma concentrations of prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyrotropin (TSH) and growth hormone (GH) were assessed. Intravenous administration of dynorphin-A(1–13), 1–120 µg/kg, significantly increased plasma PRL levels. Average maximal increases of 90–230% occurred within 5 min and levels remained significantly elevated for up to 120 min. PRL response reached a plateau following the 30 µg/kg dose. Dynorphin-A(1–13) had no observable effects on plasma concentrations of LH, FSH, TSH or GH at any dose level studied. Administration of dynorphin-A(1–10)-amide produced significant dose-dependent increases in plasma PRL concentrations. Dose levels of 1–120 µg/kg produced mean peak increases from 100 to 230%, 5–10 min postadministration. Dynorphin-A(1–10)-amide had no significant effect on plasma concentrations of LH, FSH, TSH or GH. The increases in plasma PRL concentrations induced by dynorphin-A were naloxone-reversible. These results indicate a selective effect of dynorphin-A on the regulatory mechanisms of PRL secretion over that of other anterior
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