Vascular Smooth Muscle Activity of 7-Oxa-13-Prostynoic Acid
作者:
Nobuyuki Ozaki,
Jai D. Kohli,
Leon I. Goldberg,
Josef Fried,
期刊:
Journal of Vascular Research
(Karger Available online 1979)
卷期:
Volume 16,
issue 1
页码: 52-57
ISSN:1018-1172
年代: 1979
DOI:10.1159/000158190
出版商: S. Karger AG
关键词: Prostaglandin analogs;PGE2;PGF2α;Vascular smooth muscle;7-Oxa-13-prostynoic acid;PG receptors
数据来源: Karger
摘要:
The effects of 7-oxa-13-prostynoic acid (7-OPA), alone and as an antagonist of PGE2 and PGF2α, were investigated in isolated rabbit aortic and canine renal arterial (diameter ∼0.5 mm) strips. 7-OPA caused contractions in both preparations; threshold concentrations were 3-to 10-fold higher than the PGs and maximum contraction was 50-60%. In concentrations of 10–5 M, 7-OPA inhibited contractions by PGF2α and PGE2. The same concentration of 7-OPA did not inhibit norepinephrine-induced contractions. These data indicate that 7-OPA is a partial agonist of PG receptors and produces its antagonism of PGE2 and PGF2α by that mec
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