The Role of the Low Resistance Period in Determining the Effective Dosage of Chlortetracycline in Mice
作者:
W. Sackmann,
期刊:
Chemotherapy
(Karger Available online 1971)
卷期:
Volume 16,
issue 3
页码: 196-202
ISSN:0009-3157
年代: 1971
DOI:10.1159/000220727
出版商: S. Karger AG
关键词: Experimental chemotherapy;Host resistance;Mouse;Bacteriostasis;Bacterial infections;Serum concentrations;Chlortetracycline
数据来源: Karger
摘要:
In various experimental infections inthe mouse, the single doses of chlortetracycline were determined which, when given simultaneously with the infection, prevent death of the animals. Serum concentrations of the antibiotic were measured in mice treated with 80–100% effective doses. During the initial period of infection, which is characterized by insufficient defence (low resistance period), these concentrations are invariably above or approximately equal to the minimum bacteriostatic concentration established in vitro. Hence, it is concluded that in animal experiments the dosage is dependent not only on the in vitro sensitivity of the infectious agent but also on the length of the LRP, during which the micro-organisms have to be controlled by a bacteriostatic agen
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