Chronic Bromocriptine Administration Restores Luteinizing Hormone Response to Naloxone in Postmenopausal Women
作者:
Gian Benedetto Melis,
Angelo Cagnacci,
Marco Gambacciani,
Anna Maria Paoletti,
Tiziana Caffi,
Piero Fioretti,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 47,
issue 2
页码: 159-163
ISSN:0028-3835
年代: 1988
DOI:10.1159/000124907
出版商: S. Karger AG
关键词: Luteinizing hormone;Bromocriptine;Naloxone;Postmenopausal women
数据来源: Karger
摘要:
To evaluate whether dopaminergic treatment may modify endogenous opioid activity at the hypothalamic-pituitary level, the effects of naloxone infusion (1.6 mg/h for 4 h) on luteinizing hormone (LH) secretion were studied in 5 postmenopausal women either before or after chronic administration of the dopaminergic drug bromocriptine (BCT; 5 mg/day for 30 days). BCT administration did not modify mean plasma LH levels. Before treatment naloxone infusion did not induce any significant modification of LH secretion. Conversely, after chronic BCT administration naloxone induced a significant (p < 0.05) increase in plasma LH levels. The LH response to naloxone was significantly (p < 0.001) higher than that observed before BCT. The present data show that chronic BCT administration restores the LH response to naloxone in postmenopausal women. Therefore, these results seem to demonstrate that BCT administration can enhance opioid activity, suggesting an involvement of the endogenous opioid system in dopaminergic modulation of gonadotropin release.
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