A rapid, specific and reliable high performance liquid chromatographic assay of bromocriptine mesylate in tablets has been developed. Reverse phase chromatography was conducted using a mobile phase of 0.05 M ammonium acetate and acetonitrile, (40% v/v) pH 5.6 and detection at 240 nm. The % recovery and coefficient of variation from six placebo tablets containing 2.5 mg of bromocriptine mesylate were 100.65 and 0.456 respectively. Replicate regression analyses of three standard plots in the concentration range 0.5 - 10 mcg/mL obtained on three different days gave a correlation coefficient <0.9997 and the coefficient of variation of the slopes <0.1%. The assay was precise within day and between days as indicated by ANOVA test. The percentage recoveries from 10 replicate tablets of two commercial brands was 99.4 and 102.8% of the label amount and their coefficients of variation were 1.51 and 1.07%.