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Stereoselective routes to some unsaturated α- and β-C-glycopyranosides

 

作者: Bert Fraser-Reid,   Robert David Dawe,   Deen Bhandu Tulshian,  

 

期刊: Canadian Journal of Chemistry  (NRC Available online 1979)
卷期: Volume 57, issue 13  

页码: 1746-1749

 

ISSN:0008-4042

 

年代: 1979

 

DOI:10.1139/v79-279

 

出版商: NRC Research Press

 

数据来源: NRC

 

摘要:

4,6-O-Benzylidene-D-allal,1a, undergoes the Eschenmoser–Claisen rearrangement giving the unsaturated α-C-hex-2-enopyranoside,4(3,7-anhydro-6,7-O-benzylidene-4,5-dideoxy-D-lyxo-oct-4 -N,N-dimethyl amide) in 85% yield. The corresponding β-anomer13a(methyl 3,7-anhydro-6,7-O-benzylidene-4,5-dideoxy-D-ribo-oct-4- enonate) is prepared by reductive elimination of the β-C-glucopyranoside11. The latter is obtained as the sole product from 4,6-O-ethylidene-D-glucose in two steps involving Wittig addition of carboxymethylene followed by cyclization of the resulting α,β-unsaturated ester under thermodynamic conditions.

 

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