Prothymosinαand Factors from Calf Thymic Cells Decrease Expression of Thy 1.2 Antigen Among Small Thymocs from C57BL/6 Mice
作者:
BaaPrimitivo,
FreireManuel,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1994)
卷期:
Volume 16,
issue 3
页码: 403-418
ISSN:0892-3973
年代: 1994
DOI:10.3109/08923979409007101
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractIn this work we studied the effect of Prothymosinα(ProTα) and other thymic factors on the expression of Thy 1.2 antigen (a T-cell marker) and the activities of adenosine deaminase (ADA, E.C. 3.5.4.4), N-acetyl-ß-D-glucosaminidase (NABG, E.C. 3.2,1.30),ß-glucuronidase (BG, E.C. 3.1.1.1) and serine-esterase (SE, E.C. 3.4.21)., the levels of which change during the T-cell differentiation process among small thymocytes obtained from C57BL/6 mice. Incubation of small thymocytes in the presence of ProTα, Thymus Extracts (TE) or supernatants prepared from thymic stromal cells (TSCS) or thymocytes (TS) reduced the proportion of cells killed by anti-Thy 1.2 monoclonal antibodies but did not affect the enzymatic activities studied. This is the first evidence that ProTαaffects Thy 1.2 expression in vitro.
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