Correlation ofin vitroResistance of Staphylococcus aureus to Tetracycline, Doxycycline, and Minocycline within vivoUse
作者:
Sue A. Lewis,
William A. Altemeier,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 5
页码: 319-323
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221939
出版商: S. Karger AG
关键词: Staphylococcus aureus;Tetracycline;Doxycycline;Minocycline;In vitrosensitivity testing
数据来源: Karger
摘要:
Susceptibility of 983 isolates of Staphyloccus aureus to tetracycline, doxycycline and minocycline was determined in vitro. Minocycline was shown to be more active than doxcycline, which in turn was shown to be slightly more active than tetracycline. 77% of the isolates which were resistant to tetracycline were also resistant to doxycycline, whereas only 4% of the tetracycline-resistant isolates were resistant to minocycline. The in vivo use of tetracycline correlated with increased in vitro resistance of S. aureus to tetracycline and doxycycline. A correlation between use of tetracycline and in vitro resistance to minocycline was not demonstrated.
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